Man Utd on the bubble for a record 19th top flight title and Man City with a chance to win their first silverware since 1976.
United are at Blackburn and Man City play Stoke at Wembley in the FA Cup final.
Ryan Giggs makes his 573rd appearance the most in the Premier League going past David James (572).
Two relegation threatened clubs - Blackpool and Wolves are in the limelight pitted against Bolton and Sunderland respectively. Mick McCarthy has to overcome an adverse record at the Stadium of Light to breathe easier.
Ian Holloway's side has gotten off to a bright start leading Bolton, 2-1 at Bloomfield Road.
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