Santi Cazorla, Villareal's versatile presence in the midfield will miss the Arsenal match with an ankle fracture sustained in the Liga encounter with CD Almeria. In fact, the Spanish international will be out for four months or more.
In better news for the club, Marcos Senna and Cani are back, in time to help their squad in this crucial encounter.
Robert Pires talks about how he looks forward to playing his former club. He was voted as Arsenal's sixth greatest player.
Arsenal will also see Pascal Cygan, who did yeoman duty as a makeshift left back following injuries to Ashley Young and Gael Clichy in the 2005-2006 season. He joined Pires in a transfer to Villareal in the summer of 2006.